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1.) Nanocomposite hydrogel

2.) Nanomaterials for theranostics

Hydrogel offers a soft, low solid to water content and cell-favourable environment for tissue engineering. A nanocomposite content could additionally functionalize the hydrogel network for more purposes in need.

Reference: Nano Lett. 2020, 20 (5), 3207-3216; Sci. Adv. 2023, 9(27), eadg9593

Synthesis of monodisperse, stimuli-responsive and well-defined nanoparticle is highly desirable for targeted drug-delivery, tumour killing and molecular probing

Reference: Aggregate, 2022, 4(1), e195; ACS Biomater. Sci. Eng., 2020, 6, 7, 3778–3783; Theranostics, 2022, 12(13):5914-5930

3.) Understanding cell behaviours by biomaterials


Developing tailor-made biomaterials is useful for the regulation of cell fate and mechanistic understanding of cellular behaviours before inventing translational medicine.

Reference: Sci. Adv. 2023, 9(27), eadg9593;

Nano Lett. 2021, 21, 7, 3225–3236; Adv. Funct. Mater., 2019, 29 (8): 1806822


(+Equal Contributions, *Corresponding Authors:)


53. Bohan Yin, Siu Hong Dexter Wong, G. Roshan Deen, Jeffrey S. Bates, Abhishek Pachauri, Renad AlAnsari, Jiří Hájek, Shiao-Wen Tsai*, Jagan Mohan Dodda* and N. Asmaki. 2024 (Under Review)

52. +Li, C, +Yin, B., Zhang, Q., Yan, J., Huang, Y., Chen, J., Yang, M.,* Wong, S.H.D.*, 2024 (Submitted)

51. +Zhang, Q., +Li, C., Yin, B., Yan, J., Gu, Y., Huang, Y., Chen, J., Wong, S.H.D.*, Yang, M.,* 2024 (Under Review)

50. Wang, X., Xie, X., Li, Z., Zhang, X., Yang, B., Kang, H., Yung, P.S.H., Gao, Z., Wong, S.H.D*, Zhang, K.*, Bian, L.*, Catalysis-mediated dynamic ligand presentation regulates mechanosensing–metabolism coupling of stem cells, Nano Today 2024, 57, 102363 [Link]


49. +Huang, Y., +Zhang, Q., Lam, C.Y., Li, C., Chen, Y., Zhang, R., Zhong, Z., Yan, J., Chen, J., *Yin, B., *Wong, S.H.D., *Yang, M., An Aggregation-Induced Emission-Based Dual Emitting Nanoprobe for Detecting Intracellular pH and Unravelling Metabolic Variations in Differentiating Lymphocytes, ACS Nano 2024, 18, 24, 15935–15949 [Link]

48. Wang, H., Chen, Z., Li, T., Xie, H., Yin, B., Wong, S.H.D., Shi, Y., Zhang, A.P., Optofluidic chip with directly printed polymer optical waveguide Mach-Zehnder interferometer sensors for label-free biodetection, Biomed. Opt. Express 2024, 15(5), 3240-3250  [Link] [Editor's Pick]

47. Yin, B., Gosecka, M., Bodaghi, M., Crespy, D., Youssef, G., *Dodda, J. M., *Wong, S.H.D., Imran, A. B., Gosecki, M., Jobdeedamrong, A., Naniz, M. A., Zolfagharian, A., Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications, Chem. Eng. J., 2024, 487, 150403 [Link]

46. Chen, J., Ho, W.K.H., Yin, B., Zhang, Q., Li, C., Yan, J., Huang, Y., Hao, J., Yi, C., Zhang, Y., *Wong, S.H.D., *Yang, Mo, Magnetic-responsive upconversion luminescence resonance energy transfer (LRET) biosensor for ultrasensitive detection of SARS-CoV-2 spike protein, Biosens. Bioelectron., 2024, 248, 115969 [Link]


45. Yin, B., Zhang, Q., Yan, J., Huang, Y., Li, C., Chen, J., Wen, W., *Wong, S.H.D., *Yang, M., Nanomanipulation of Ligand  Nanogeometry Modulates Integrin/Clathrin-Mediated Adhesion and Endocytosis of Stem Cells, Nano Lett. 2023, (19), 9160–9169 [Link] (Selected Cover in Nano Letters Volume 23, Issue 19)

44. Zou, S., Wang, F., Cheng, J*., Wong, S.H.D., Mechanism of cold plasma combined with glycation in altering IgE-binding capacity and digestion stability of tropomyosin from shrimp, J. Agric. Food Chem., 2023, 71 (42), 15796–15808 [Link]

43. +Wong, S.H.D., +Yin, B., Li, L., Yuan, W., Zhang, Q., Xie, X., Tan, Y., Wong, N, *Zhang, K., *Bian, L., Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling, Sci. Adv. 2023, 9(27), eadg9593 [Link] (Featured in iNature Wechat subscription) (Feature in 高分子科技 WeChat subscriptions) (Featured in BioMed科技Wechat subscriptions)

42. Yin, B., Wong, W.K., Ng, Y.M., Yang, M., *Leung, F.K.C., *Wong, S.H.D., Smart Design of Nanostructures for Boosting Tumor Immunogenicity in Cancer Immunotherapy, Pharmaceutics 2023, 15(5), 1427 [Link]

41. Zhang, Q., Yin B., Huang, Y., Gu, Y., Yan, J., Chen, J., Li, C., Zhang, Y., *Wong, S.H.D., *Yang, M., A dual "turn-on" biosensor based on AIE effect and FRET for in situ detection of miR- 125b biomarker in early Alzheimer's disease, Biosens. Bioelectron., 2023, 230, 115270 [Link]

40. Huang, Y., Yin, B., *Wong, S.H.D., Multicomponent Hydrogels in Clinical and Pharmaceutical Applications, Royal Society of Chemistry Books - Multicomponent Hydrogels: Smart Materials for Biomedical Applications, 2023, Chapter-14, 449-501 [Link]

39. Yin, B.,  Ho, W. K. H., Xia, X. Y., Chan, C. K. W. Zhang, Q., Ng, Y. M., Lam, C. Y. K., Wang, J. F., *Yang, M., *Wong, S. H. D., A multilayered mesoporous gold nanoarchitecture for ultraeffective near-infrared light-controlled chemo/photothermal therapy for cancer guided by SERS imaging, Small, 2023, 19(6), 2206762 [Link] [Hot Topic: Mesoporous Materials (Small)] [Hot Topic: Surfaces and Interfaces (Advanced Materials Interfaces)] [Selected for Frontispiece in (Small 6/2023) Link

(As of March/April 2023 , this 🏆 highly cited paper received enough citations to place it in the top 1% of the academic field of Materials Science based on a highly cited threshold for the field and publication year.) (Featured in 化学与材料科学Wechat subscription)

38. Wong, S.H.D., Deen, G.R., Bates, J.S., Maiti, C, Lam, C.Y.K., Pachauri, A., AlAnsari, R., Belsky, P., Yoon, J., Dodda, J.M., Smart skin-adhesive patches: From design to biomedical applications, Adv. Funct. Mater., 2023, 2213560 [Link] [Hot topic: Flexible Electronics (Advanced Intelligent Systems)]


37. Yin, B., Zhang, Q., Xia, X., Li, C., Ho, W.K.H., Yan, J., Huang, Y., Wu, H., Wang, P., Yi, C., Hao, J., Wang, J., Chen, H., *Wong, S.H.D., *Yang, M., A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection, Theranostics, 2022, 12(13):5914-5930 [Link] (Featured in Theranostics WeChat subscription(Feature in PolyU Vibrant@FENG - Issue 4, Major theme story 2023)

36. Zhang, Q., Yin, B., Ma, L., Huang, Y., Shao, X., Li, C., Chu, Z., Hao, J., *Wong, S.H.D.; *Yang, M., An AIEgen/graphene oxide nanocomposite (AIEgen@GO)-based two-stage “turn-on” nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence. Aggregate, 2022, 4(1), e195 (Featured in Aggregate WeChat subscription(Feature in PolyU Vibrant@FENG - Issue 4, Major theme story 2023)

35. Yin, B., Ho, W.K.H., Zhang, Q., Li, C., Huang, Y., Yan, J., Yang, H., Hao, J., *Wong, S.H.D., *Yang, M.,  Magnetic-Responsive Surface-Enhanced Raman Scattering Platform with Tunable Hot Spot for Ultrasensitive Virus Nucleic Acid Detection. ACS Appl. Mater. Interface, 2022, 14(3), 4714–4724 [Link] (Featured in PolyU Vibrant@FENG - Issue 3, Jul/Aug. 2022) [Link]

34. +WONG, W. K.; +Yin, B.; Lam, C. Y. K.; *Tan, Z.; *Wong, S.H.D. The Interplay Between Epigenetic Regulation and CD8+ T cell Differentiation/Exhaustion for T cell Immunotherapy Front. Cell Dev. Biol. 2022, 9:783227 [Link]

33. Zhang, Y., Wu H., Wang H., Yin B., Wong S.H.D., Zhang A.P., Tam H.Y., Ultraminiature optical fiber-tip directly-printed plasmonic biosensors for label-free biodetection, Biosens. Bioelectron, 2022, 218, 114761 [Link]

32. Oh, J., Xia, X., Wong, W.K.R., Wong, S.H.D., Yuan, W., Wang, H., Lai, C.H.N., Tian, Y., Ho, Y.P., Zhang H., Zhang, Y., Li, G., Lin, Y.*, Bian, L.*, The effect of the nanoparticle shape on T cell activation, Small, 2022, 18 (36), 2107373 [Link]


31. Yin, B.; Ni, J.; Witherel, C. E.; Yang, M., *Burdick, J. A.; *Wen, C.; *Wong, S.H.D. Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics Theranostics, 2021, 12(1): 207-231 [Link]

(Featured in Theranostics WeChat subscription) (As of September/October 2022, this 🏆highly cited paper received enough citations to place it in the top 1% of the academic field of Clinical Medicine based on a highly cited threshold for the field and publication year. — Data from Essential Science Indicators)

30. +Zhang, J.; +Wong, S. H. D.; Wu, X.; Lei, H,; Qin, M.; Shi, P.; *Wang, W.; *Bian, L.; *Cao, Y. Engineering Photo-responsive Ligand Tethers for Mechanical Regulation of Stem Cells Adv. Mater. 2021, 33(48): 2105765 [Link(Feature in PolyU Vibrant@FENG - Issue 3, Jul/Aug. 2022)

29. +Lam, C. Y. K.; +Zhang, Q.; Yin, B.; Huang, Y.; Wang, H.; *Yang M.; *Wong, S.H.D. Recent Advances in Two-dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection Before and During COVID-19 outbreak J. Compos. Sci. 2021, 5(7), 190 (Special issue review, highly accessed article) [Link]

28. +WONG, W. K.; +Yin, B.; Rakhmatullina, A.; *Zhou, J.; *Wong, S.H.D. Engineering Advanced Dynamic Biomaterials to Optimize Adoptive T-cell Immunotherapy. Eng. Regen. 2021, 2, 70–81 (Invited perspective/review) [Link]

(Featured in EngineeredRegeneration再生工程 WeChat subscription)


27. +Wong, S. H. D.; +Xu X.; +Chen X.; Xin Y.; Xu L.; Lai C. H. N.; Oh J.; Wong W. K.; Wang X.; Han S.; You W.; Shuai X.; Wong N.; *Tan Y.; *Li D.; *Bian L. Manipulation of the nanoscale presentation of integrin ligand produces cancer cells with enhanced stemness and robust tumorigenicity. Nano Lett. 2021, 21, 7, 3225–3236 [Link]

(Featured in PolyU Vibrant@FENG - Issue 2, Dec. 2021)

26. +Yang, B.; +Wei, K; Loebel, C.; Zhang, K.; Feng, Q; Li, R.; Wong S.H.D.; Xu, X.; Lau, C.; Chen, X.; Zhao, P.; Yin, C; Professor Burdick, J.; *Wang, Yi; *Bian, L. Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics Nat. Comm. 2021, 12 (1), 1-13 [Link]

25. Huang, J.; Yang, B.; Peng, Y.; Huang, J.; Wong, S. H. D.; Bian, L.; *Zhu K.; *Shuai X.; *Han S. Nanomedicine-Boosting Tumor Immunogenicity for Enhanced Immunotherapy, Adv. Funct. Mater. 2021, 202011171 [Link]


+Wong, W.K.R.; +Wong, S.H.D.; *Bian, L. Long-Term Detection of Oncogenic MicroRNA in Living Human Cancer Cells by Gold@Polydopamine–Shell Nanoprobe. ACS Biomater. Sci. Eng., 2020, 6, 7, 3778–3783 [Link]

24. Wong, S.H.D.; Wong, W.K.R.; Lai, N.C.H.; Oh, J.; Li, Z.; Chen, X.; Yuan, W.; *Bian, L. Soft polymeric matrix as a macroscopic cage for magnetically modulating reversible nanoscale ligand presentation. Nano Lett., 2020, 20, 5, 3207-3216 [Link

(Featured in 高分子科技 WeChat subscriptions)

23. +Chen, X.; +Lai, N.C.H.; +Wei, K.; Li, R.; Cui, M.; Yang, B.; Wong, S.H.D.; Deng, Y.; Li, J.; Shuai, X.; *Bian, L. Biomimetic presentation of cryptic ligands via single-chain nanogels for synergistic regulation of stem cells". ACS Nano 2020, 14, 4, 4027–4035 [Link]

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22. Yin, B., Chan, C.K.W., Liu, S., Hong, H., Wong, S.H.D., Lee, L.K.C., Ho, L.W.C., Zhang, L., Leung, K.C.F., Choi, P.C.L., *Bian, L., *Tian, X.Y., *Chan M.N., and *Choi C.H.J., Intrapulmonary Cellular-Level Distribution of Inhaled Nanoparticles with Defined Functional Groups and Its Correlations with Protein Corona and Inflammatory Response. ACS Nano, 2019, 13(12): 14048-14069. [Link]

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21. Chen, X.; Li, R; Wong, S.H.D.; Wei, K.; et al.; Xia, J.; Chen, G.; Li, G.; *Bian, L. Conformational manipulation of scale-up prepared single-chain polymeric nanogels for multiscale regulation of cells, Nat. Comm., 2019, 10: 2705 [Link]

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(Highlighted by CUHK communications and public relations office)

20. +Kang, H.; +Wong, S.H.D.; Pan, Q..; Li, G.; *Bian, L., Anisotropic ligand nanogeometry modulates the adhesion and polarization state of macrophages, Nano Lett., 2019, 19(3): 1963-1975 [Link]

19. +Wong, S.H.D.; +Yin, B.; Lin S.; Yang, B.; Li, R.; Feng, F.; Yang, H.; Zhang, L.; Yang, Z.; Li, G.; *Choi, C. H.; *Bian, L., Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing-dependent differentiation of stem cells, Adv. Funct. Mater., 2019, 29 (8): 1806822 [Link]

Highlighted by Nat. Rev. Bioeng. 2024 "Nanoscale anisotropy for biomedical applications" Figure 3b [Link]


18. +Kang, H.; Jung, H.J.; Kim, S.K.; Wong, S.H.D.; Lin, S.; Li, G.; Dravid, V.; *Bian, L. Magnetic manipulation of reversible nanocaging controls in vivo adhesion and polarization of macrophages, ACS Nano, 2018, 12(6): 5978-5994. [Link]

17. +Yin, C.; +Wen, G.; Liu, C.; Yang, B.; Lin, S.; Huang, J.; Zhao, P.; Wong, S.H.D., Zhang, K.; Chen, X.; Li, G.; Jiang, X.; *Pu, K.; *Wang, L.; *Bian, L. Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window. ACS Nano, 2018, 12 (12): 12201–2211. [Link]

(Featured in 材料牛cailiaoniu)

16. +Kang, H.; +Zhang, K.; Pan, Q.; Lin, S.; Wong, S.H.D.; Li, J.; Lee, Y. W.; Yang, B.; Han, F.; *Li, B.; *Bian, L., Remote control of intracellular calcium using upconversion nanotransducers regulates stem cell differentiation in vivo, Adv. Funct. Mater., 2018, 28 (41): 201802642. [Link]

15. Li, J.; Lee, Y. W.; Wu, T.; Leung, Y.T.C; Xu, J.; Wong, S.H.D.; Li, R.; *Li, G.; *Tang, B.Z.; *Bian, L., Detection of Matrix Metallopeptidase 13 for Monitoring Stem Cell Differentiation and Early Diagnosis of Osteoarthritis by Fluorescent Light‐Up Probes with Aggregation‐Induced Emission Characteristics, Adv. Biosys., 2018, 2(10): 1800010 [Link]

14. Gao S., Tung W.T., S.H.D. Wong, Bian L., *Zhang A., Direct optical micropatterning of poly (dimethylsiloxane) for microfluidic devices J. Micromech. Microeng. 28 (9), 095011 [Link]

13. +Kang, H.; Jung, H.J.; Kim, S.K.; Wong, S.H.D.; Lin, S.; Li, G.; Dravid, V.; *Bian, L., Magnetic Manipulation of Reversible Nanocaging Controls In Vivo Adhesion and Polarization of Macrophages, ACS Nano, 2018, 12 (6): 5978–994. [Link]

12. +Li, R.; +Li, J.; Xu, J.; Wong, S.H.D.; Chen, X.; Yuan, W.; *Bian, L. Multiscale reconstruction of a synthetic biomimetic micro-niche for enhancing and monitoring the differentiation of stem cells. Biomater., 2018,173: 87-99 [Link]

11. +Kang, H.; + Jung, H.J.; Wong, S.H.D.; Kim, S.K.; Lin, S.; Chan, K.F.; Zhang, L.; Li, G.; Dravid, V.; *Bian, L. Remote control of heterodimeric magnetic nanoswitch regulates the adhesion and differentiation of stem cells. J. Am. Chem. Soc., 2018;140 (18): 5909-5913. [Link]

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Published in 2019 JACS Young Investigators Virtual Issue

10. +Kang, H.; +Zhang, K.; Wong, S.H.D.; Han, H.; Li, B.; Liming; *Bian, L. Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization. Biomater., 2018, 178:681-696 [Link]


9. Zhao, P.; Wei, K.; Feng, Q.; Chen, H.; Wong, S.H.D.; Chen, X.; *Bian, L. Mussel-mimetic hydrogels with defined cross-linkers achieved by controlled catechol dimerization exhibiting tough adhesion for wet biological tissues. Chem. Comm., 2017, 53: 12000-12003. [Link]

8. +Kang, H.; +Kim, S.; Wong, S.H.D.; Jung, H.J.; Lin, Si.; Zou, K.; Li, R.; Li, G.; *Dravid, V.; *Bian, L. Remote manipulation of ligand nano-oscillations regulates adhesion and polarization of macrophages in vivo. Nano Lett., 2017, 17 (10): 6415-6427 [Link]

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7. +Kang, H.; +Wong, S.H.D.; Yan, X.; Jung, H.J.; King, S.K.; Lin, Si.; Wei, K.; Li, G.; *Dravid, V.; *Bian, L. Remote control of multi-Modal nanoscale ligand oscillations regulates stem cell adhesion and differentiation, ACS Nano, 2017, 11(10): 9636-9649 [Link]

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6. +Wong, S.H.D.; +Li, J.; Yan, X.; Wang, B., Zhang, L.; *Bian, L. Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells, Nano Lett., 2017, 17 (3): 1685-1695 [Link]

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5. +Li, R.; +Xu, J.; Wong, S.H.D.; Li, J.; Zhao, P.; *Bian, L.; Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/β-catenin signaling. Biomaterials, 2017, 145: 33-43. [Link]

4. +Ouyang, X.; +Zhang, K.; Wu, J.; Wong, S.H.D.; Feng, Q.; *Bian, L.; *Zhang, A. Optical μ-Printing of Cellular-Scale Microscaffold Arrays for 3D Cell Culture, Sci. Rep., 2017, 7 (1): 8880 [Link]

3. Li, J.; Yan, X.; Leung, Y.T.C; Wong, S.H.D.; Xu, J.; Li, R.; Zhao, Y.; Yung, Y.Y.C; Zhao, E.; *Tang, B.Z.; *Bian, L. Photo-controlled siRNA delivery and biomarker-triggered AIEgen emission by upconversion NaYF4:Yb3+Tm3+@SiO2 nanoparticles for inducing and monitoring stem cell differentiation, ACS Appl. Mater. Interfaces, 2017, 11 (25): 22074-22084 [Link]


2. +Li, J.; +Lee, Y. W.; Wu, T.; Xu, J.; Zhang, K.; Wong, S.H.D.; Li, R.; *Li, G.; *Bian, L. Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles. Biomaterials, 2016, 110: 1-10 [Link]

1. Shaorui Gao, Wing-Tai Tung, Wong, S.H.D, Liming Bian, *A Ping Zhang. Direct optical patterning of poly (dimethylsiloxane) microstructures for microfluidic chips. AOMATT 2016 Oct; 96850X-96850X-6 [Link]

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