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A biomimetic H2 nanogenerator for Alzheimer's disease!

Updated: Sep 1


Highlights


  • Utilized biocompatible crosslinked vesicles (CVs) to developed biomimetic upconversion nanoreactors for in situ hydrogen (H2) generation under near-infrared (NIR) light.

  • Showcased the high photocatalytic efficiency of the nanoreactors by encapsulating dual photosensitizers (Chla + Ind), mimicking natural photosynthesis processes.

  • Achieved NIR-controlled and localized H2 release to effectively mitigate oxidative stress and significantly inhibit tau hyperphosphorylation in Alzheimer's disease (AD) mice model.

  • Provided a novel proof-of-concept for the potential of NIR-triggered hydrogen therapy as a treatment for neurodegenerative diseases like AD.

This work has been published in Bioactive Materials [Link: https://www.sciencedirect.com/science/article/pii/S2452199X24003670]


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