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A magnetic-responsive platform to regulate cell fate through integrin-ligand binding modulations

Updated: Mar 31, 2021

Magnetically Tuning Tether Mobility of Integrin Ligand Regulates Adhesion, Spreading, and Differentiation of Stem Cells

Schematic illustration of the potential mechanism underlying the substrate tether mobility to control hMSCs adhesion, spreading, and differentiation, which is governed by mechanosensing signaling. (a) Without magnetic field, RGD-bearing MNPs are mobile along the tether. A high tether mobility gives unstable RGD-integrin binding anchorage and hence leads to delayed maturation of FA complexes and F-actin filament assembly. Therefore, cell spreading is poor, and the cell shape remains relatively spindle. Such behavior may leads to delayed mechanosensing signaling (e.g., YAP signaling), which inhibits hMSC differentiation. (b) With downward continuous magnetic field, RGD-bearing MNPs are attracted downward, and the tether mobility is restricted. The substrate provides a stable RGD-integrin binding anchorage and leads to normal maturation of FA complexes and F-actin filament assembly. Such event allows hMSCs to spread well. Mechanosensing signaling (e.g., YAP) will be upregulated to promote hMSC differentiation.

It is really exciting to have my first publication!

Well, I don't know what to post yet so I put my first representative publication in this post :D!


Reference:

+Wong, S.H.D.; +Li, J.; Yan, X.; Wang, B., Zhang, L.; *Bian, L. Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells, Nano Lett, 2017, 17 (3): 1685-1695


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